BCL2 (124) on tonsil.
BCL2 (124) Mouse Monoclonal Antibody
Specialties: Hematopathology
Updated: 2017-06-01 11:04:26
Bcl-2 family is the best characterized protein family involved in regulation of apoptotic cell death, consisting of anti-apoptotic and pro-apoptotic members. Bcl-2 is a useful marker for identifying neoplastic cells in follicular lymphoma. Antibodies specific for the Bcl-2 protein can be used to distinguish between reactive and neoplastic follicular proliferation in lymph node biopsies.1-4
- Tsujimoto, Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells. 1998; 3:697-707.
- Gaulard P, et al. Expression of the bcl-2 gene product in follicular lymphoma. Am J Pathol. 1992; 140: 1089-95.
- Wang T, et al. Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value. APMIS. 1995; 103:655-62.
- West RB, et al. The usefulness of immunohistochemistry in the diagnosis of follicular lymphoma in bone marrow biopsy specimens. Am J Clin Pathol. 2002; 117:636-43.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 5.0 (CMC22629050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 226M-90 |
| 0.1 mL concentrate | 226M-94 |
| 0.5 mL concentrate | 226M-95 |
| 1 mL concentrate | 226M-96 |
| 1 mL predilute | 226M-97 |
| 7 mL predilute | 226M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 226M-90 |
| 0.1 mL concentrate | 226M-94 |
| 0.5 mL concentrate | 226M-95 |
| 1 mL concentrate | 226M-96 |
| 1 mL predilute | 226M-97 |
| 7 mL predilute | 226M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 226M-90 |
| 0.1 mL concentrate | 226M-94 |
| 0.5 mL concentrate | 226M-95 |
| 1 mL concentrate | 226M-96 |
| 1 mL predilute | 226M-97 |
| 7 mL predilute | 226M-98 |
For research use only (RUO) in Japan
| 25 mL predilute | 226M-90-RUO |
| 0.1 mL concentrate | 226M-94-RUO |
| 0.5 mL concentrate | 226M-95-RUO |
| 1 mL concentrate | 226M-96-RUO |
| 1 mL predilute | 226M-97-RUO |
| 7 mL predilute | 226M-98-RUO |
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