CD63 (NKI/C3) on skin.
CD63 (NKI/C3) Mouse Monoclonal Antibody
Specialties: Dermatopathology
Updated: 2017-05-24 08:46:09
CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and the majority of malignant melanomas. Anti-CD63 is a useful immunohistochemical marker for the identification of malignant melanoma.1-4
- Azorsa DO, et al. CD63/Pltgp40: a platelet activation antigen identical to the stage-specific, melanoma-associated antigen ME491. Blood. 1991; 78:280-4.
- Barrio MM, et al. A new epitope on human melanoma-associated antigen CD63/ME491 expressed by both primary and metastatic melanoma. Hybridoma. 1998; 17:355-64.
- Demetrick DJ,et al. ME491 melanoma-associated glycoprotein family: antigenic identity of ME491, NKI/C-3, neuroglandular antigen (NGA), and CD63 proteins. J Natl Cancer Inst. 1992; 84:422-9.
- Mete O, et al. Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch. 2005; 447:938-46.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: melanoma
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC26321030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 263M-14 |
| 0.5 mL concentrate | 263M-15 |
| 1 mL concentrate | 263M-16 |
| 1 mL predilute | 263M-17 |
| 7 mL predilute | 263M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 263M-14 |
| 0.5 mL concentrate | 263M-15 |
| 1 mL concentrate | 263M-16 |
| 1 mL predilute | 263M-17 |
| 7 mL predilute | 263M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 263M-14 |
| 0.5 mL concentrate | 263M-15 |
| 1 mL concentrate | 263M-16 |
| 1 mL predilute | 263M-17 |
| 7 mL predilute | 263M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 263M-14-RUO |
| 0.5 mL concentrate | 263M-15-RUO |
| 1 mL concentrate | 263M-16-RUO |
| 1 mL predilute | 263M-17-RUO |
| 7 mL predilute | 263M-18-RUO |
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