Ep-CAM/Epithelial Specific Antigen (MOC-31) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Cytopathology
Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues.1 Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression.2 Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes.1,2 In conjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelial origin, such as distinguishing between lung adenocarcinoma and mesothelioma.2-4
- Schnell U, et al. EpCAM: structure and function in health and disease. Biochim Biophys Acta. 2013; 1828:1989-2001.
- Latza U, et al. Ber-Ep4: New monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol. 1990; 43:213-19.
- Ordóñez NG. Value of the Ber-Ep4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma: the M.D. Anderson experience and a critical review of the literature. Am J Clin Pathol. 1998; 109:85-9.
- Ordóñez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003; 27:1031-51.
Specifications
- Reactivity: paraffin
- Control: Colon adenocarcinoma (Cytoplasmic, Membranous)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC24821050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 248M-10 |
| 0.1 mL concentrate | 248M-14 |
| 0.5 mL concentrate | 248M-15 |
| 1.0 mL concentrate | 248M-16 |
| 1.0 mL predilute ready-to-use | 248M-17 |
| 7.0 mL predilute ready-to-use | 248M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 248M-10 |
| 0.1 mL concentrate | 248M-14 |
| 0.5 mL concentrate | 248M-15 |
| 1.0 mL concentrate | 248M-16 |
| 1.0 mL predilute ready-to-use | 248M-17 |
| 7.0 mL predilute ready-to-use | 248M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 248M-10 |
| 0.1 mL concentrate | 248M-14 |
| 0.5 mL concentrate | 248M-15 |
| 1.0 mL concentrate | 248M-16 |
| 1.0 mL predilute ready-to-use | 248M-17 |
| 7.0 mL predilute ready-to-use | 248M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 248M-10-RUO |
| 0.1 mL concentrate (RUO) | 248M-14-RUO |
| 0.5 mL concentrate (RUO) | 248M-15-RUO |
| 1.0 mL concentrate (RUO) | 248M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 248M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 248M-18-RUO |
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