Desmin (D33) Mouse Monoclonal Antibody
Specialties: Soft Tissue Pathology
Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils.1 In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.1-4 This antibody is used to demonstrate the myogenic components/derivation of tumors.2,3 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.4
- Kouloumenta A, et al. Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin. Journal of Biological Chemistry. 2007; 282:35211-21.
- Altmannsberger M, et al. Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 1985; 118:85-95.
- Debus E, et al. Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 1983; 2:2305-12.
- Yamaguchi U, et al. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch. 2004; 2:142-50.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: skeletal muscle
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC24321040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 243M-14 |
| 0.5 mL concentrate | 243M-15 |
| 1 mL concentrate | 243M-16 |
| 1 mL predilute | 243M-17 |
| 7 mL predilute | 243M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 243M-14 |
| 0.5 mL concentrate | 243M-15 |
| 1 mL concentrate | 243M-16 |
| 1 mL predilute | 243M-17 |
| 7 mL predilute | 243M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 243M-14 |
| 0.5 mL concentrate | 243M-15 |
| 1 mL concentrate | 243M-16 |
| 1 mL predilute | 243M-17 |
| 7 mL predilute | 243M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 243M-14-RUO |
| 0.5 mL concentrate | 243M-15-RUO |
| 1 mL concentrate | 243M-16-RUO |
| 1 mL predilute | 243M-17-RUO |
| 7 mL predilute | 243M-18-RUO |
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