Actin, Smooth Muscle (1A4) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Soft Tissue Pathology
Detection of smooth muscle actin in myoepithelial and smooth muscle cells by immunohistochemistry (IHC) with Actin, Smooth Muscle (1A4) Mouse Monoclonal Antibody may be used to aid in the diagnosis of breast carcinomas, leiomyomas, and leiomyosarcomas.
Smooth muscle actin is a member of the actin family of proteins, which are structural proteins of the cytoskeleton that are present in all cells. Smooth muscle actin is expressed specifically in smooth muscle cells, myoepithelial cells, and myofibroblasts, but not in skeletal muscle or other cell types.1-3 Identification of myoepithelial cells is used to aid in the diagnosis of invasive breast carcinoma. Smooth muscle actin expression is also seen in tumors arising from smooth muscle including leiomyomas and leiomyosarcomas.2-3 Immunohistochemistry for smooth muscle actin shows a cytoplasmic pattern of staining.
In combination with other antibodies, this product may be used as an aid in diagnosis.
- Cooke, P."A filamentous cytoskeleton in vertebrate smooth muscle fibers."The Journal of cell biology vol. 68,3 (1976): 539-56.
- Skalli, O et al."A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation."The Journal of cell biology vol. 103,6 Pt 2 (1986): 2787-96.
- Perez-Montiel, Maria Delia et al."Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue."The American Journal of dermatopathology vol. 28,2 (2006): 105-11.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish perox idase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Appendix (Cytoplasmic); Uterus (Cytoplasmic); Vessel wall (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC20229070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 202M-90 |
| 0.1 mL concentrate | 202M-94 |
| 0.5 mL concentrate | 202M-95 |
| 1.0 mL concentrate | 202M-96 |
| 1.0 mL predilute ready-to-use | 202M-97 |
| 7.0 mL predilute ready-to-use | 202M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 202M-90 |
| 0.1 mL concentrate | 202M-94 |
| 0.5 mL concentrate | 202M-95 |
| 1.0 mL concentrate | 202M-96 |
| 1.0 mL predilute ready-to-use | 202M-97 |
| 7.0 mL predilute ready-to-use | 202M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 202M-90 |
| 0.1 mL concentrate | 202M-94 |
| 0.5 mL concentrate | 202M-95 |
| 1.0 mL concentrate | 202M-96 |
| 1.0 mL predilute ready-to-use | 202M-97 |
| 7.0 mL predilute ready-to-use | 202M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 202M-90-RUO |
| 0.1 mL concentrate (RUO) | 202M-94-RUO |
| 0.5 mL concentrate (RUO) | 202M-95-RUO |
| 1.0 mL concentrate (RUO) | 202M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 202M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 202M-98-RUO |
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