Cytokeratin, HMW (AE3) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Anti-cytokeratin, high molecular weight (AE3) is capable of recognizing all basic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. Members of the acidic and basic subfamilies are found together in pairs. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium.1-5
- Tyler CR. Immunoperoxidase techniques: practical and theoretical aspects. Arch Pathol Lab Med. 1978; 102:113-21.
- Weiss RA, et al. Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol. 1984; 98:1397-406.
- Lopez-Beltrán A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. Virchows Arch. 2001; 438:552-7.
- Nelson WG, et al. The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol. 1983; 97:244-51.
- Sun TT, et al. Monoclonal antibody studies of mammalian epithelial keratins: a review. Ann N Y Acad Sci. 1985; 455:307-29.
Specifications
- Reactivity: paraffin
- Control: Bladder (Cytoplasmic); Salivary gland (Cytoplasmic); Prostate (Cytoplasmic)
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 5.0 (CMC30321050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 303M-14 |
| 0.5 mL concentrate | 303M-15 |
| 1.0 mL concentrate | 303M-16 |
| 1.0 mL predilute ready-to-use | 303M-17 |
| 7.0 mL predilute ready-to-use | 303M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 303M-14 |
| 0.5 mL concentrate | 303M-15 |
| 1.0 mL concentrate | 303M-16 |
| 1.0 mL predilute ready-to-use | 303M-17 |
| 7.0 mL predilute ready-to-use | 303M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 303M-14 |
| 0.5 mL concentrate | 303M-15 |
| 1.0 mL concentrate | 303M-16 |
| 1.0 mL predilute ready-to-use | 303M-17 |
| 7.0 mL predilute ready-to-use | 303M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 303M-14-RUO |
| 0.5 mL concentrate (RUO) | 303M-15-RUO |
| 1.0 mL concentrate (RUO) | 303M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 303M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 303M-18-RUO |
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