Chromogranin A (LK2H10) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, thyroid, and parathyroid.1-3 Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin.1-3 It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms.
- Fischer-Colbrie R, et al. Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues. Neuroscience. 1985; 16:547-55.
- Hearn SA. Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. J Histochem Cytochem. 1987; 35:795-801.
- Wilson BS, et al. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol. 1984; 115:458-68.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: pancreas
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC23829040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 238M-90 |
| 0.1 mL concentrate | 238M-94 |
| 0.5 mL concentrate | 238M-95 |
| 1 mL concentrate | 238M-96 |
| 1 mL predilute | 238M-97 |
| 7 mL predilute | 238M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 238M-90 |
| 0.1 mL concentrate | 238M-94 |
| 0.5 mL concentrate | 238M-95 |
| 1 mL concentrate | 238M-96 |
| 1 mL predilute | 238M-97 |
| 7 mL predilute | 238M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 238M-90 |
| 0.1 mL concentrate | 238M-94 |
| 0.5 mL concentrate | 238M-95 |
| 1 mL concentrate | 238M-96 |
| 1 mL predilute | 238M-97 |
| 7 mL predilute | 238M-98 |
For research use only (RUO) in Japan
| 25 mL predilute | 238M-90-RUO |
| 0.1 mL concentrate | 238M-94-RUO |
| 0.5 mL concentrate | 238M-95-RUO |
| 1 mL concentrate | 238M-96-RUO |
| 1 mL predilute | 238M-97-RUO |
| 7 mL predilute | 238M-98-RUO |
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