IDH1 R132H (MRQ-67) Rabbit Monoclonal Antibody

IDH1 R132H
IDH1 R132H (MRQ-67) on myeloproliferative neoplasm, bone marrow

IDH1 R132H (MRQ-67) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2019-08-26 16:04:20

Isocitrate dehydrogenase 1 (IDH1) functions as an enzyme in the Krebs (citric acid) cycle and is biologically active in the cytoplasmic and peroxisomal compartments under normal conditions.  The occurrence of heterozygous missense mutations at an arginine residue at codon 132 (R132) within the coding region for the substrate binding site of IDH1 has been described to promote oncogenesis in several malignancies.1 Of the identified mutant variants, R132H is one of the more frequently observed point mutations in cancer patients and has been immunohistochemically described in a subset of acute myeloid leukemia cases.2

  1. Yang, H, et al. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res. 2012; 18:5562-5571.
  2. Kurt, H, et al. Characterization of IDH1 p.R132H Mutant Clones Using Mutation-specific Antibody in Myeloid Neoplasms. Am J Surg Pathol. 2018; 42:569-577.

Specifications


  • Reactivity: paraffin
  • Control: Acute myeloid leukemia (Cytoplasmic)
  • Dilution Range: 1:25-1:100 *

Package Inserts


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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate456R-34
0.5 mL concentrate456R-35
1.0 mL concentrate456R-36
1.0 mL predilute ready-to-use456R-37
7.0 mL predilute ready-to-use456R-38

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