TdT (EP266) Rabbit Monoclonal Antibody
Specialties: Hematopathology Pediatric Pathology
TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T-cell antigen receptors.1 TdT expression is characteristic of lymphoid progenitor cells in thymus and tonsils.2 Anti-TdT is a useful marker for lymphoblastic lymphomas3 and has been observed in some cases of acute myeloid leukemia.4
- Motea EA, et al. Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. Biochimica et Biophysica Acta. 2010; 1804:1151-66.
- Stauchen JA, et al. Lymphoid progenitor cells in human tonsils. Int J Surg Pathol. 2003; 11:21-4.
- Suzumiya J, et al. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol. 1997; 182:86-91.
- Arber DA, et al. Paraffin section immunophenotyping of acute leukemias in bone marrow specimens. Am J Clin Pathol. 1996; 106:462-8.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: thymus
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC33832020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 338R-24 |
| 0.5 mL concentrate | 338R-25 |
| 1 mL concentrate | 338R-26 |
| 1 mL predilute | 338R-27 |
| 7 mL predilute | 338R-28 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 338R-24 |
| 0.5 mL concentrate | 338R-25 |
| 1 mL concentrate | 338R-26 |
| 1 mL predilute | 338R-27 |
| 7 mL predilute | 338R-28 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 338R-24 |
| 0.5 mL concentrate | 338R-25 |
| 1 mL concentrate | 338R-26 |
| 1 mL predilute | 338R-27 |
| 7 mL predilute | 338R-28 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 338R-24-RUO |
| 0.5 mL concentrate | 338R-25-RUO |
| 1 mL concentrate | 338R-26-RUO |
| 1 mL predilute | 338R-27-RUO |
| 7 mL predilute | 338R-28-RUO |
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