PAX-5 (EP156) Rabbit Monoclonal Antibody
Specialties: Hematopathology
PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5.4 PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation.1,3 Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.1-4
- Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50.
- Willenbrock K, et al. Lab Invest. 2002; 82:1103-9.
- Falini B, et al. Blood. 2002; 99:409-26.
- Schwering I, et al. Blood. 2003; 101:1505-12.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC31232030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 312R-20 |
| 0.1 mL concentrate | 312R-24 |
| 0.5 mL concentrate | 312R-25 |
| 1 mL concentrate | 312R-26 |
| 1 mL predilute | 312R-27 |
| 7 mL predilute | 312R-28 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 312R-20 |
| 0.1 mL concentrate | 312R-24 |
| 0.5 mL concentrate | 312R-25 |
| 1 mL concentrate | 312R-26 |
| 1 mL predilute | 312R-27 |
| 7 mL predilute | 312R-28 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 312R-20 |
| 0.1 mL concentrate | 312R-24 |
| 0.5 mL concentrate | 312R-25 |
| 1 mL concentrate | 312R-26 |
| 1 mL predilute | 312R-27 |
| 7 mL predilute | 312R-28 |
For research use only (RUO) in Japan
| 25 mL predilute | 312R-20-RUO |
| 0.1 mL concentrate | 312R-24-RUO |
| 0.5 mL concentrate | 312R-25-RUO |
| 1 mL concentrate | 312R-26-RUO |
| 1 mL predilute | 312R-27-RUO |
| 7 mL predilute | 312R-28-RUO |
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