TTF-1 (EP229) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Pulmonary Pathology
Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid1-2, germ cell tumors3, and malignant mesothelioma.4-5 It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.6 TTF-1 labeling is also seen in thyroid and thyroid-derived tumors.7 TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions.8 TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.9
- Bejarano PA, et al. Mod Pathol. 1996; 9:445-52.
- Holzinger A, et al. Hybridoma. 1996; 15:49-53.
- Saad RS, et al. Appl Immunohistochem Mol Morphol. 2003; 11:107-12.
- Di Loreto C, et al. Cancer Lett. 1998; 124:73-8.
- Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8.
- Di Loreto C, et al. J Clin Pathol. 1997; 50:30-2.
- Katoh R, et al. Mod Pathol. 2000; 13:570-6.
- Jang KY, et al. Anal Quant Cytol Histol. 2001; 23:400-4.
- Srodon M, et al. Hum Pathol. 2002; 33:642-5.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: lung adenocarcinoma
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC34331010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 343R-14 |
| 0.5 mL concentrate | 343R-15 |
| 1 mL concentrate | 343R-16 |
| 1 mL predilute | 343R-17 |
| 7 mL predilute | 343R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 343R-14 |
| 0.5 mL concentrate | 343R-15 |
| 1 mL concentrate | 343R-16 |
| 1 mL predilute | 343R-17 |
| 7 mL predilute | 343R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 343R-14 |
| 0.5 mL concentrate | 343R-15 |
| 1 mL concentrate | 343R-16 |
| 1 mL predilute | 343R-17 |
| 7 mL predilute | 343R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 343R-14-RUO |
| 0.5 mL concentrate | 343R-15-RUO |
| 1 mL concentrate | 343R-16-RUO |
| 1 mL predilute | 343R-17-RUO |
| 7 mL predilute | 343R-18-RUO |
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