GATA3 (L50-823) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Breast/Gynecological Pathology Genitourinary (GU) Pathology
GATA binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.1-4 The human GATA3 gene has been mapped to chromosome 10p15.3 GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma.1-2 Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.
- Higgins JP, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007; 31:673-80.
- Liu, H, et al. Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol. 2012; 138:57-64.
- Joulin V, et al. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 1991; 10: 1809-16.
- Labastie M, et al. Structure and expression of the human GATA3 gene. Genomics; 21:1-6.
Specifications
- Reactivity: paraffin
- Control: Breast carcinoma (Nuclear); Urothelial carcinoma (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC39021040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 390M-10 |
| 0.1 mL concentrate | 390M-14 |
| 0.5 mL concentrate | 390M-15 |
| 1.0 mL concentrate | 390M-16 |
| 1.0 mL predilute ready-to-use | 390M-17 |
| 7.0 mL predilute ready-to-use | 390M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 390M-10 |
| 0.1 mL concentrate | 390M-14 |
| 0.5 mL concentrate | 390M-15 |
| 1.0 mL concentrate | 390M-16 |
| 1.0 mL predilute ready-to-use | 390M-17 |
| 7.0 mL predilute ready-to-use | 390M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 390M-10 |
| 0.1 mL concentrate | 390M-14 |
| 0.5 mL concentrate | 390M-15 |
| 1.0 mL concentrate | 390M-16 |
| 1.0 mL predilute ready-to-use | 390M-17 |
| 7.0 mL predilute ready-to-use | 390M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 390M-10-RUO |
| 0.1 mL concentrate (RUO) | 390M-14-RUO |
| 0.5 mL concentrate (RUO) | 390M-15-RUO |
| 1.0 mL concentrate (RUO) | 390M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 390M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 390M-18-RUO |
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