LMO2 (SP51) Rabbit Monoclonal Antibody
Specialties: Hematopathology
The LIM-domain-only (LMO) family of proteins function as linkers in the co-regulation of nuclear transcription by mediating protein-protein interactions. The four members of the LMO family collectively have significant roles in cell fate determination, cell growth and differentiation, and organ development.1 LMO2 has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymphangiogenesis.2 Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.3 The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.
- Sang M, et al. LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins. Mol Biol Rep. 2014; 41:1067-73.
- Coma S, et al. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. 2013; 16:939-52.
- Natkunam Y, et al. The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. Blood. 2007; 109:1636-42.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil, follicular lymphoma, diffuse large B-cell lymphoma
- Dilution Range: 1:500-1:2000*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC37031030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 370R-14 |
| 0.5 mL concentrate | 370R-15 |
| 1 mL concentrate | 370R-16 |
| 1 mL predilute | 370R-17 |
| 7 mL predilute | 370R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 370R-14 |
| 0.5 mL concentrate | 370R-15 |
| 1 mL concentrate | 370R-16 |
| 1 mL predilute | 370R-17 |
| 7 mL predilute | 370R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 370R-14 |
| 0.5 mL concentrate | 370R-15 |
| 1 mL concentrate | 370R-16 |
| 1 mL predilute | 370R-17 |
| 7 mL predilute | 370R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 370R-14-RUO |
| 0.5 mL concentrate | 370R-15-RUO |
| 1 mL concentrate | 370R-16-RUO |
| 1 mL predilute | 370R-17-RUO |
| 7 mL predilute | 370R-18-RUO |
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