Melanoma tumor cells are stained by the PNL2 antibody in a cytoplasmic pattern.
PNL2 (PNL2) Mouse Monoclonal Antibody
Specialties: Dermatopathology
Updated: 2017-05-24 08:46:09
Anti-PNL2 is useful as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. Anti-PNL2 reactivity is identified in the cytoplasm of cutaneous and oral mucosal melanocytes. Anti-PNL2 labels intraepidermal nevi, while the dermal components of compound nevi are largely non-reactive.1-4
- Rochaix P, et al. PNL2, a new monoclonal antibody directed against a fixative-resistant melanocyte antigen. Mod Pathol. 2003; 16:481-90.
- Klaus J, et al. Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers. Am J Surg Pathol. 2005; 29:400-6.
- Morris LG, et al. PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck. Head Neck. 2008; 30:771-5.
- Zhe X, et al. Combined smooth muscle and melanocytic differentiation in lymphangioleiomyomatosis. J Histo and Cyto. 2004; 52:1537-42.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: melanoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC36529030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 365M-94 |
| 0.5 mL concentrate | 365M-95 |
| 1 mL concentrate | 365M-96 |
| 1 mL predilute | 365M-97 |
| 7 mL predilute | 365M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 365M-94 |
| 0.5 mL concentrate | 365M-95 |
| 1 mL concentrate | 365M-96 |
| 1 mL predilute | 365M-97 |
| 7 mL predilute | 365M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 365M-94 |
| 0.5 mL concentrate | 365M-95 |
| 1 mL concentrate | 365M-96 |
| 1 mL predilute | 365M-97 |
| 7 mL predilute | 365M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 365M-94-RUO |
| 0.5 mL concentrate | 365M-95-RUO |
| 1 mL concentrate | 365M-96-RUO |
| 1 mL predilute | 365M-97-RUO |
| 7 mL predilute | 365M-98-RUO |
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