Caldesmon antibody labels myoepithelial cells of adenosis in a cytoplasmic staining pattern.
Caldesmon (E89) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology
Updated: 2022-10-13 14:15:07
Caldesmon is a regulatory protein which plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle.1-3 It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.4,5
- Miettinen, Markku, and Jerzy Lasota. "Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis." Archives of pathology & laboratory medicine vol. 130,10 (2006): 1466-78.
- Watanabe, K et al. "h-Caldesmon in leiomyosarcoma and tumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor." Human pathology vol. 30,4 (1999): 392-6.
- McCluggage, W Glenn. "A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms." Advances in anatomic pathology vol. 11,3 (2004): 162-71.
- Comin, Camilla E et al. "h-Caldesmon, a useful positive marker in the diagnosis of pleural malignant mesothelioma, epithelioid type." The American journal of surgical pathology vol. 30,4 (2006): 463-9.
- Comin, Camilla E et al. "h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary." The American journal of surgical pathology vol. 31,8 (2007): 1139-48.
Specifications
- Reactivity: paraffin
- Control: Appendix (Cytoplasmic); Breast (Cytoplasmic)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC23031050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 230R-14 |
| 0.5 mL concentrate | 230R-15 |
| 1.0 mL concentrate | 230R-16 |
| 1.0 mL predilute ready-to-use | 230R-17 |
| 7.0 mL predilute ready-to-use | 230R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 230R-14 |
| 0.5 mL concentrate | 230R-15 |
| 1.0 mL concentrate | 230R-16 |
| 1.0 mL predilute ready-to-use | 230R-17 |
| 7.0 mL predilute ready-to-use | 230R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 230R-14 |
| 0.5 mL concentrate | 230R-15 |
| 1.0 mL concentrate | 230R-16 |
| 1.0 mL predilute ready-to-use | 230R-17 |
| 7.0 mL predilute ready-to-use | 230R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 230R-14-RUO |
| 0.5 mL concentrate (RUO) | 230R-15-RUO |
| 1.0 mL concentrate (RUO) | 230R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 230R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 230R-18-RUO |
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