Podoplanin (D2-40) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Detection of podoplanin by immunohistochemistry with Podoplanin (D2-40) Mouse Monoclonal Antibody may be used to identify lymphatics and to aid in the diagnosis of epithelioid mesotheliomas and seminomas.
Podoplanin is a transmembrane glycoprotein that plays a role in development of the heart, lungs, and lymphatic system and is recognized by the monoclonal antibody D2-40. Podoplanin is expressed in several normal tissue types including lymphatic endothelium, mesothelium, and fetal testis. Podoplanin expression in lymphatic endothelium makes it a useful marker to identify tumor lymph vascular invasion.1-3 Podoplanin is also expressed in epithelioid mesotheliomas and seminomas.1,4,5 Podoplanin immunohistochemistry shows a cytoplasmic pattern of staining.
- Ordóñez, Nelson G. "Podoplanin: a novel diagnostic immunohistochemical marker." Advances in anatomic pathology vol. 13,2 (2006): 83-8.
- Niakosari, Firouzeh et al. "Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium." Archives of dermatology vol. 141,4 (2005): 440-4.
- Fukunaga, M. "Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours." Histopathology vol. 46,4 (2005): 396-402.
- Ordóñez, Nelson G. "D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma." Human pathology vol. 36,4 (2005): 372-80.
- Chu, Albert Y et al. "Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 18,1 (2005): 105-10.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic, Membranous)
- Dilution Range: 1:20-1:100 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC32221070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 322M-10-RUO |
| 0.1 mL concentrate (RUO) | 322M-14-RUO |
| 0.5 mL concentrate (RUO) | 322M-15-RUO |
| 1.0 mL concentrate (RUO) | 322M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 322M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 322M-18-RUO |
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