Tumor cells on classical seminoma of testis express cytoplasmic staining of anti-PLAP.
PLAP (SP15) Rabbit Monoclonal Antibody
Specialties: Genitourinary (GU) Pathology
Updated: 2017-05-24 08:46:09
Placental Alkaline Phosphatase (PLAP) belongs to a family of four isozymes that are synthesized in primordial germ cells and in term placental syncytiotrophoblasts.1 Anti-PLAP may be useful in the identification of germ cell tumors.2-4
Note: This product is in obsolescence. PLAP (NB10) is available as an alternative.
- Goldsmith JD, et al. Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation. Am J Surg Pathol. 2002; 26:1627-33.
- Fishman L, et al. Developmental phase-specific alkaline phosphatase isoenzymes of human placenta and their occurrence in human cancer. Cancer Res. 1976; 36:2268-73.
- Ravenni N, et al. A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer. mAbs. 2014; 6:86-94.
- Jacobsen GK, et al. Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. Acta Pathol Microbiol Immunol Scand A. 1984; 92:323-9.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: placenta
- Dilution Range: 1:500-1:1000*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC32131040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 321R-14 |
| 0.5 mL concentrate | 321R-15 |
| 1 mL concentrate | 321R-16 |
| 1 mL predilute | 321R-17 |
| 7 mL predilute | 321R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 321R-14 |
| 0.5 mL concentrate | 321R-15 |
| 1 mL concentrate | 321R-16 |
| 1 mL predilute | 321R-17 |
| 7 mL predilute | 321R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 321R-14 |
| 0.5 mL concentrate | 321R-15 |
| 1 mL concentrate | 321R-16 |
| 1 mL predilute | 321R-17 |
| 7 mL predilute | 321R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 321R-14-RUO |
| 0.5 mL concentrate | 321R-15-RUO |
| 1 mL concentrate | 321R-16-RUO |
| 1 mL predilute | 321R-17-RUO |
| 7 mL predilute | 321R-18-RUO |
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