Inhibin, alpha (R1) Mouse Monoclonal Antibody
Specialties: Genitourinary (GU) Pathology
Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary.1-2 Inhibin is a dimer that consists of an alpha and beta subunit.1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex.2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.3-9
- Munro LM, et al. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol. 1999; 161:341-7.
- McCluggage WG, et al. Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. J Clin Pathol. 1998; 51: 114-6.
- Stewart CJ, et al. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology. 1997; 31:67-74.
- Yamashita K, et al. Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol. 1997; 177:1450-7.
- McCluggage WG, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol. 1998; 22:615-9.
- Kommoss F, et al. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol. 1998; 11:656-64.
- Iczkowski KA, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998; 11:774-9.
- Guerrieri C, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol. 1998; 17:266-71.
- McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol. 2000; 53:327-34.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: adrenal cortex
- Dilution Range: 1:5-1:100*
Package Inserts
IFU
- IVD Rev. 5.0 (CMC27121050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 271M-14 |
| 0.5 mL concentrate | 271M-15 |
| 1 mL concentrate | 271M-16 |
| 1 mL predilute | 271M-17 |
| 7 mL predilute | 271M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 271M-14 |
| 0.5 mL concentrate | 271M-15 |
| 1 mL concentrate | 271M-16 |
| 1 mL predilute | 271M-17 |
| 7 mL predilute | 271M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 271M-14 |
| 0.5 mL concentrate | 271M-15 |
| 1 mL concentrate | 271M-16 |
| 1 mL predilute | 271M-17 |
| 7 mL predilute | 271M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 271M-14-RUO |
| 0.5 mL concentrate | 271M-15-RUO |
| 1 mL concentrate | 271M-16-RUO |
| 1 mL predilute | 271M-17-RUO |
| 7 mL predilute | 271M-18-RUO |
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