Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Anti-cytokeratin cocktail (AE1 & AE3) is a broad-spectrum keratin antibody cocktail.1-3 It is composed of mouse monoclonal antibody AE1 that recognizes acidic type I keratins 10, 14, 15, 16, 19, and AE3 that reacts with basic type II keratins 1, 2, 3, 4, 5, 6, 7, and 8. Both clones were generated using epidermal keratin as immunogen.1-3 This antibody is useful for identifying cells of epithelial origin and detects most carcinomas of different primary sites.1,2 This antibody cocktail can cross-react with other intermediate filaments, such as glial fibrillary acidic protein, giving a false-positive staining in glial tumors.4
- Battifora, H. "Clinical applications of the immunohistochemistry of filamentous proteins." The American journal of surgical pathology vol. 12 Suppl 1 (1988): 24-42.
- Cooper, D et al. "Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations." Laboratory investigation; a journal of technical methods and pathology vol. 52,3 (1985): 243-56.
- Gown, A M, and A M Vogel. "Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors." American journal of clinical pathology vol. 84,4 (1985): 413-24.
- Kriho, V K et al. "Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment." Virchows Archiv : an international journal of pathology vol. 431,2 (1997): 139-47.
Specifications
- Reactivity: paraffin
- Control: Breast (Cytoplasmic); Lung (Cytoplasmic); Colon (Cytoplasmic); Skin (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC31321060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 313M-14-RUO |
| 0.5 mL concentrate (RUO) | 313M-15-RUO |
| 1.0 mL concentrate (RUO) | 313M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 313M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 313M-18-RUO |
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