CD57 (NK-1) Mouse Monoclonal Antibody
Specialties: Hematopathology
CD57, also known as HNK-1 (human natural killer-1), is a cell surface carbohydrate epitope expressed on terminally differentiated T-cells and subsets of natural killer (NK) cells.1 It has also been identified on cells of neural crest origin.2 CD57 antibodies are often used to visualize non-neoplastic bystander T-cells.3 These T-cells have been known to form rosettes around neoplastic lymphocyte-predominant (LP) cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).3
- Kared, Hassen et al. "CD57 in human natural killer cells and T-lymphocytes." Cancer immunology, immunotherapy : CII vol. 65,4 (2016): 441-52.
- Nielsen, Carolyn M et al. "Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease." Frontiers in immunology vol. 4 422. 9 Dec. 2013
- Sattarzadeh, Ahmad et al. "CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma." Experimental hematology & oncology vol. 4 27. 15 Sep. 2015
- Agarwal, Rashmi et al. "Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study." Journal of oral and maxillofacial pathology : JOMFP vol. 20,2 (2016): 173-7.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC15729060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 157M-94 |
| 0.5 mL concentrate | 157M-95 |
| 1.0 mL concentrate | 157M-96 |
| 1.0 mL predilute ready-to-use | 157M-97 |
| 7.0 mL predilute ready-to-use | 157M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 157M-94 |
| 0.5 mL concentrate | 157M-95 |
| 1.0 mL concentrate | 157M-96 |
| 1.0 mL predilute ready-to-use | 157M-97 |
| 7.0 mL predilute ready-to-use | 157M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 157M-94 |
| 0.5 mL concentrate | 157M-95 |
| 1.0 mL concentrate | 157M-96 |
| 1.0 mL predilute ready-to-use | 157M-97 |
| 7.0 mL predilute ready-to-use | 157M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 157M-94-RUO |
| 0.5 mL concentrate (RUO) | 157M-95-RUO |
| 1.0 mL concentrate (RUO) | 157M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 157M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 157M-98-RUO |
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