CD21 (2G9) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of CD21 in follicular dendritic cells (FDC) by immunohistochemistry (IHC) with CD21 (2G9) Mouse Monoclonal Antibody may be used to aid in the diagnosis of follicular dendritic cell sarcomas and follicular lymphomas.
CD21, also known as complement receptor 2, C3d receptor and Epstein-Barr virus (EBV) receptor, is a 140-kD membrane protein expressed on B-lymphocytes to which the EBV binds during infection of these cells.1 CD21 is expressed primarily on follicular dendritic cells and mature B-lymphocytes found in normal lymph node and tonsillar tissue and is absent on T-lymphocytes, monocytes, and granulocytes.2,3 Anti-CD21 is useful in the identification of the follicular dendritic cell framework in lymphomas, particularly follicular lymphomas, and is also expressed in follicular dendritic cell sarcoma, a malignancy deriving from follicular dendritic cells.2,4-6 Immunohistochemistry for CD21 shows a cytoplasmic or membranous pattern of staining.
- Cheuk, W et al. "Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association." The American journal of surgical pathology vol. 25,6 (2001): 721-31.
- Pileri, S A et al. "Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases." Histopathology vol. 41,1 (2002): 1-29.
- Maeda, Kunihiko et al. "Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol. 50,11 (2002): 1475-86.
- Biddle, David A et al. "Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 15,1 (2002): 50-8.
- Chan, A C et al. "Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies." Histopathology vol. 38,6 (2001): 510-8.
- Chang, Kong-Chao et al. "Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma." The Journal of pathology vol. 201,3 (2003): 404-12.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic, Membranous)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC12121060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 121M-14 |
| 0.5 mL concentrate | 121M-15 |
| 1.0 mL concentrate | 121M-16 |
| 1.0 mL predilute ready-to-use | 121M-17 |
| 7.0 mL predilute ready-to-use | 121M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 121M-14 |
| 0.5 mL concentrate | 121M-15 |
| 1.0 mL concentrate | 121M-16 |
| 1.0 mL predilute ready-to-use | 121M-17 |
| 7.0 mL predilute ready-to-use | 121M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 121M-14 |
| 0.5 mL concentrate | 121M-15 |
| 1.0 mL concentrate | 121M-16 |
| 1.0 mL predilute ready-to-use | 121M-17 |
| 7.0 mL predilute ready-to-use | 121M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 121M-14-RUO |
| 0.5 mL concentrate | 121M-15-RUO |
| 1.0 mL concentrate (RUO) | 121M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 121M-17-RUO |
| 7.0 mL predilute ready-to-use | 121M-18-RUO |
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