h-Caldesmon (hHCD) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Soft Tissue Pathology
Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer.1 In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.2
- Nucci, MR, et al. h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. Am J Surg Pathol. 2001; 25(4):455-463.
- Ceballos, KM, et al. Is anti-h-caldesmon useful for distinguishing smooth muscle and myofibroblastic tumors? An immunohistochemical study. Am J Clin Pathol. 2000; 114(5):746-753.
Specifications
- Reactivity: paraffin
- Control: Stomach (Cytoplasmic); Smooth Muscle (Cytoplasmic); Bladder (Cytoplasmic); Colon (Cytoplasmic); Leiomyoma (Cytoplasmic)
- Dilution Range: 1:50-1:100 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC45121000)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 451M-14 |
| 0.5 mL concentrate | 451M-15 |
| 1.0 mL concentrate | 451M-16 |
| 1.0 mL predilute ready-to-use | 451M-17 |
| 7.0 mL predilute ready-to-use | 451M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 451M-14 |
| 0.5 mL concentrate | 451M-15 |
| 1.0 mL concentrate | 451M-16 |
| 1.0 mL predilute ready-to-use | 451M-17 |
| 7.0 mL predilute ready-to-use | 451M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 451M-14 |
| 0.5 mL concentrate | 451M-15 |
| 1.0 mL concentrate | 451M-16 |
| 1.0 mL predilute ready-to-use | 451M-17 |
| 7.0 mL predilute ready-to-use | 451M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 451M-14-RUO |
| 1.0 mL concentrate (RUO) | 451M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 451M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 451M-18-RUO |
To request information on this product in additional countries, please click the button below.
