PHOX2B (EP312) Rabbit Monoclonal Antibody
Specialties: Neuropathology Pediatric Pathology
Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p135 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype.2 The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS.1,3-4 Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas.3,5 PHOX2B has been reported to be negative in other small round blue cell tumors.3
- Bourdeaut F, et al. Cancer Lett. 2005; 228:51-58.
- Pattyn A, et al. Nature. 1999; 399:366-70.
- Bielle F, et al. Am J Surg Pathol. 2012; 36:1141-49.
- Longo L, et al. Int J Oncol. 2008; 33:985-91.
- Nonaka D, et al. Am J Surg Pathol. 2013; 37:1236-41.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: neuroblastoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC42231010)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 422R-14 |
| 0.5 mL concentrate | 422R-15 |
| 1 mL concentrate | 422R-16 |
| 1 mL predilute | 422R-17 |
| 7 mL predilute | 422R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 422R-14 |
| 0.5 mL concentrate | 422R-15 |
| 1 mL concentrate | 422R-16 |
| 1 mL predilute | 422R-17 |
| 7 mL predilute | 422R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 422R-14 |
| 0.5 mL concentrate | 422R-15 |
| 1 mL concentrate | 422R-16 |
| 1 mL predilute | 422R-17 |
| 7 mL predilute | 422R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 422R-14-RUO |
| 0.5 mL concentrate | 422R-15-RUO |
| 1 mL concentrate | 422R-16-RUO |
| 1 mL predilute | 422R-17-RUO |
| 7 mL predilute | 422R-18-RUO |
To request information on this product in additional countries, please click the button below.
