Villin (EP163) Rabbit Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium.1 This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs.2-5 This antibody also labels Merkel cells of the skin.6
- Leong AS-Y, et al. Manual of diagnostic antibodies for immnunohistochemistry. London: Greenwich Medical Media Ltd. 1999. Print. p. 162-168.
- Tan J, et al. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 1998; 29:390-6.
- Goldstein NS, et al. Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies. Am J Clin Pathol. 2001; 116:319-25.
- Tamboli P, et al. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: a report of 7 cases and investigation using a limited immunohistochemical panel. Arch Pathol Lab Med. 2002; 126:1057-63.
- Zhang PJ, et al. Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. Arch Pathol Lab Med. 1999; 123:812-6.
- Toyoshima K, et al. Identification of Merkel cells by an antibody to villin. J Histochem Cytochem. 1998; 46:1329-34.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: colon
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC34631020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 346R-14 |
| 0.5 mL concentrate | 346R-15 |
| 1 mL concentrate | 346R-16 |
| 1 mL predilute | 346R-17 |
| 7 mL predilute | 346R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 346R-14 |
| 0.5 mL concentrate | 346R-15 |
| 1 mL concentrate | 346R-16 |
| 1 mL predilute | 346R-17 |
| 7 mL predilute | 346R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 346R-14 |
| 0.5 mL concentrate | 346R-15 |
| 1 mL concentrate | 346R-16 |
| 1 mL predilute | 346R-17 |
| 7 mL predilute | 346R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 346R-14-RUO |
| 0.5 mL concentrate | 346R-15-RUO |
| 1 mL concentrate | 346R-16-RUO |
| 1 mL predilute | 346R-17-RUO |
| 7 mL predilute | 346R-18-RUO |
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