Hairy cell leukemia cells show a moderate membranous staining reaction by CD11c antibody.
CD11c (5D11) Mouse Monoclonal Antibody
Specialties: Hematopathology
Updated: 2017-05-24 08:46:09
CD11c is an adhesion receptor of the leukocyte function-associated family of molecules. Reportedly CD11c is expressed in hairy cell leukemia whereas the majority of other small B-cell lymphomas do not express CD11c antigen. This indicates that immunohistochemical staining of formalin-fixed biopsies with anti-CD11c can be useful for identification of hairy cell leukemia.1-4
- Korinna J, et al. A novel CD I monoclonal antibody effective in formalin-fixed tissue for the diagnosis of hairy cell leukemia. Pathobiology. 2008; 75:252-6.
- Went PT, et al. High specificity of combined TRAP and DBA.44 expression for hairy cell leukaemia. Am J Surg Pathol. 2005; 29:474-8.
- Miranda RN, et al. Immunohistochemical detection of cyclin Dl using optimized conditions is highly specific for mantle cell lymphoma and hairy cell leukaemia. Modem Pathology. 2000; 13:1308-14.
- Marotta G, et al. Expression of the CD11c antigen in B-cell chronic lymphoproliferative disorders. Leuk Lymphoma. 2000; 37:145-9.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: hairy cell leukemia, granulocytes, monocytes, bone marrow
- Dilution Range: 1:20-1:80*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC11121020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 111M-14 |
| 0.5 mL concentrate | 111M-15 |
| 1 mL concentrate | 111M-16 |
| 1 mL predilute | 111M-17 |
| 7 mL predilute | 111M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 111M-14 |
| 0.5 mL concentrate | 111M-15 |
| 1 mL concentrate | 111M-16 |
| 1 mL predilute | 111M-17 |
| 7 mL predilute | 111M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 111M-14 |
| 0.5 mL concentrate | 111M-15 |
| 1 mL concentrate | 111M-16 |
| 1 mL predilute | 111M-17 |
| 7 mL predilute | 111M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 111M-14-RUO |
| 0.5 mL concentrate | 111M-15-RUO |
| 1 mL concentrate | 111M-16-RUO |
| 1 mL predilute | 111M-17-RUO |
| 7 mL predilute | 111M-18-RUO |
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