INI-1 (MRQ-27) Mouse Monoclonal Antibody
Specialties: Pediatric Pathology
INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor. Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.1-3
- Bourdeaut, F et al. "hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities." The Journal of pathology vol. 211,3 (2007): 323-30.
- Kohashi, Kenichi, and Yoshinao Oda. "Oncogenic roles of SMARCB1/INI1 and its deficient tumors." Cancer science vol. 108,4 (2017): 547-552.
- Haberler, Christine et al. "Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype." The American journal of surgical pathology vol. 30,11 (2006): 1462-8.
Specifications
- Reactivity: paraffin
- Control: Brain (Nuclear); Endothelial cells (Nuclear); Astrocytoma (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC27221060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 272M-14 |
| 0.5 mL concentrate | 272M-15 |
| 1.0 mL concentrate | 272M-16 |
| 1.0 mL predilute ready-to-use | 272M-17 |
| 7.0 mL predilute ready-to-use | 272M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 272M-14 |
| 0.5 mL concentrate | 272M-15 |
| 1.0 mL concentrate | 272M-16 |
| 1.0 mL predilute ready-to-use | 272M-17 |
| 7.0 mL predilute ready-to-use | 272M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 272M-14 |
| 0.5 mL concentrate | 272M-15 |
| 1.0 mL concentrate | 272M-16 |
| 1.0 mL predilute ready-to-use | 272M-17 |
| 7.0 mL predilute ready-to-use | 272M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 272M-14-RUO |
| 0.5 mL concentrate (RUO) | 272M-15-RUO |
| 1.0 mL concentrate (RUO) | 272M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 272M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 272M-18-RUO |
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