Scattered germinal center cells labelled with PD-1 antibody.
PD-1 (NAT105) Mouse Monoclonal Antibody
Specialties: Hematopathology
Updated: 2022-10-13 11:10:19
Programmed death-1 (PD-1), also known as CD279, is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4
- Thibult ML, et al. PD-1 is a novel regulator of human B-cell activation. Int Immunol. 2013; 25:129-37.
- Francisco L, et al. The PD-1 pathway in tolerance and autoimmunity. Immunol. 2010; 236:219-42.
- Dorfman DM, et al. Programmed Death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell Lymphoma. Am J Surg Pathol. 2006; 30:802-10.
- Cogbill CH, et al. Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates. Am J Clin Pathol. 2014; 142:88-98.
Specifications
- Reactivity: paraffin
- Control: Lymph node (Cytoplasmic); Tonsil (Cytoplasmic)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC31529070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 315M-94 |
| 0.5 mL concentrate | 315M-95 |
| 1.0 mL concentrate | 315M-96 |
| 1.0 mL predilute ready-to-use | 315M-97 |
| 7.0 mL predilute ready-to-use | 315M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 315M-94 |
| 0.5 mL concentrate | 315M-95 |
| 1.0 mL concentrate | 315M-96 |
| 1.0 mL predilute ready-to-use | 315M-97 |
| 7.0 mL predilute ready-to-use | 315M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 315M-94 |
| 0.5 mL concentrate | 315M-95 |
| 1.0 mL concentrate | 315M-96 |
| 1.0 mL predilute ready-to-use | 315M-97 |
| 7.0 mL predilute ready-to-use | 315M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 315M-94-RUO |
| 0.5 mL concentrate (RUO) | 315M-95-RUO |
| 1.0 mL concentrate (RUO) | 315M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 315M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 315M-98-RUO |
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