NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Genitourinary (GU) Pathology
Detection of NKX3.1 by immunohistochemistry (IHC) with NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody may be used to aid in the diagnosis of prostate carcinomas.
NKX3.1 is a transcription factor involved in the development of the testes and prostate. It plays an important role in normal prostate development and maintenance, regulating the proliferation of glandular epithelium and the formation of ducts in prostate. NKX3.1 is highly expressed in the luminal epithelium of the normal prostate gland and shows some expression in testes as well as minor salivary glands.1 Immunohistochemistry for NKX3.1 is positive in prostate carcinomas.2,3 Immunohistochemistry for NKX3.1 shows a nuclear pattern of staining.
- Gelmann, Edward P et al. "Expression of NKX3.1 in normal and malignant tissues." The Prostate vol. 55,2 (2003): 111-7.
- Gurel, Bora et al. "NKX3.1 as a marker of prostatic origin in metastatic tumors." The American journal of surgical pathology vol. 34,8 (2010): 1097-105.
- Chuang, Ai-Ying et al. "Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma." The American journal of surgical pathology vol. 31,8 (2007): 1246-55.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Prostate adenocarcinoma (Nuclear); Prostate (Nuclear)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC44131050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 441R-10 |
| 0.1 mL concentrate | 441R-14 |
| 0.5 mL concentrate | 441R-15 |
| 1.0 mL concentrate | 441R-16 |
| 1.0 mL predilute ready-to-use | 441R-17 |
| 7.0 mL predilute ready-to-use | 441R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 441R-10 |
| 0.1 mL concentrate | 441R-14 |
| 0.5 mL concentrate | 441R-15 |
| 1.0 mL concentrate | 441R-16 |
| 1.0 mL predilute ready-to-use | 441R-17 |
| 7.0 mL predilute ready-to-use | 441R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 441R-10 |
| 0.1 mL concentrate | 441R-14 |
| 0.5 mL concentrate | 441R-15 |
| 1.0 mL concentrate | 441R-16 |
| 1.0 mL predilute ready-to-use | 441R-17 |
| 7.0 mL predilute ready-to-use | 441R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 441R-10-RUO |
| 0.1 mL concentrate (RUO) | 441R-14-RUO |
| 0.5 mL concentrate (RUO) | 441R-15-RUO |
| 1.0 mL concentrate (RUO) | 441R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 441R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 441R-18-RUO |
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