Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1)
Cytokeratin 5 & 6 + TTF-1 (D5/16B4 + 8G7G3/1) on lung.

Cytokeratin 5 & 6 (D5/16B4) + TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

Updated: 2017-05-24 08:46:09

Anti-Cytokeratin 5 & 6 is a marker for eptihelioid mesotheliomas. Anti-Cytokeratin 5 & 6 stains the cytoplasm of such cells. Anti-TTF-1 stains the nuclei in the case of lung adenocarcinomas and is negative in nearly all mesotheliomas. The nuclear vs. cytoplasmic staining pattern of this cocktail can be useful in distinguishing between mesothelioma and adenocarcinoma of the lung.1-7

  1. Ordóñez NG. Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998; 22:1215-21.
  2. Ordóñez NG. Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas. Am J Surg Pathol. 1998; 22:1203-14.
  3. Cury PM, et al. Value of the mesothelium-associated antibodies thrombomodulin, cytokeratin 5/6, calretinin, and CD44H in distinguishing epithelioid pleural mesothelioma from adenocarcinoma metastatic to the pleura. Mod Pathol. 2000; 13:107-12.
  4. Jang KY, et al. Utility of thyroid transcription factor-1 and cytokeratin 7 and 20 immunostaining in the identification of origin in malignant effusions. Anal Quant Cytol Histol; 2001; 23:400-4.
  5. Srodon M, et al. Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases. Hum Pathol. 2002; 33:642-5.
  6. Abutaily AS, et al. Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies. J Clin Pathol. 2002; 55:662-8.
  7. Bejarano PA, et al. Incidence and significance of cytoplasmic thyroid transcription factor-1 immunoreactivity. Arch Pathol Lab Med. 2003; 127:193-5.


  • Reactivity: paraffin
  • Visualization: cytoplasmic(cytokeratin 5 & 6), nuclear
  • Control: mesothelioma, lung adenocarcinoma
  • Dilution Range: N/A*

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For in vitro diagnostic (IVD) use in USA

1 mL predilute902H-07
7 mL predilute902H-08

For in vitro diagnostic (IVD) use in Canada

1 mL predilute902H-07
7 mL predilute902H-08

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