Synaptophysin Rabbit Polyclonal Antibody
Specialties: Anatomic Pathology
Anti-synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, pituitary, thyroid, pancreas.1-2 Positive staining is seen in neurons of the brain. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms.1-5 Diffuse, finely granular cytoplasmic staining is observed which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers.3 Anti-synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
- Navone F, et al. Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol. 1986; 103:2511-27.
- Wiedenmann B, et al. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell. 1985; 41:1017-28.
- Kayser K, et al. Expression of neuroendocrine markers (neuron specific enolase, synaptophysin and bombesin) in carcinoma of the lung. Pathol Res Pract. 1988; 183:412-7.
- Conner MG, et al. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 2002; 6:345-8.
- Lyda MH, et al. Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas. Hum Pathol. 2000; 31:980-7.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: pancreas
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 5.0 (CMC33617050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 336A-70 |
| 0.1 mL concentrate | 336A-74 |
| 0.5 mL concentrate | 336A-75 |
| 1 mL concentrate | 336A-76 |
| 1 mL predilute | 336A-77 |
| 7 mL predilute | 336A-78 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 336A-70 |
| 0.1 mL concentrate | 336A-74 |
| 0.5 mL concentrate | 336A-75 |
| 1 mL concentrate | 336A-76 |
| 1 mL predilute | 336A-77 |
| 7 mL predilute | 336A-78 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 336A-70 |
| 0.1 mL concentrate | 336A-74 |
| 0.5 mL concentrate | 336A-75 |
| 1 mL concentrate | 336A-76 |
| 1 mL predilute | 336A-77 |
| 7 mL predilute | 336A-78 |
For research use only (RUO) in Japan
| 25 mL predilute | 336A-70-RUO |
| 0.1 mL concentrate | 336A-74-RUO |
| 0.5 mL concentrate | 336A-75-RUO |
| 1 mL concentrate | 336A-76-RUO |
| 1 mL predilute | 336A-77-RUO |
| 7 mL predilute | 336A-78-RUO |
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