The germinal center macrophages and intravascular neutrophils demonstrate a strong cytoplasmic reaction by the alpha-1-antitrypsin antibody.
A-1-Antitrypsin Rabbit Polyclonal Antibody
Specialties: Hematopathology
Updated: 2017-05-26 11:42:26
Alpha-1-Antitrypsin is a protease inhibitor from the serpin superfamily, which inhibits a number of protease enzymes from inflammatory cells. The immunohistochemical Anti-A-1-antitrypsin reagent has been useful in studying inherited AAT deficiency, hepatic tumors, lesions of a histiocytic nature, and cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain etiology.1-6
- Callea F, et al. Detection of Pi Z phenotype individuals by alpha-1-antitrypsin (AAT) immunohistochemistry in paraffin-embedded liver tissue specimens. J Hepatol. 1986; 2:389-401.
- Palmer PE, et al. Immunohistochemistry of liver in alpha1-antitrypsin deficiency. A comparative study. Am J Clin Pathol. 1974; 62:350-4.
- Palmer PE, et al. Expression of protein markers in malignant hepatoma: evidence for genetic and epigenetic mechanisms. Cancer. 1980; 45:1424-31.
- Kindblom LG, et al. Immunohistochemical investigations of tumors of supposed fibroblastic-histiocytic origin. Hum Pathol. 1982; 13:834-40.
- Raintoft I, et al. Does the Z gene variant of alpha-1-antitrypsin predispose to hepatic carcinoma? Hum Pathol. 1979; 10:419-24.
- Ramsay AD, et al. Variable antigen expression in hepatoblastomas. Appl Immunohistochem Mol Morphol. 2008; 16:140-7.
Specifications
- Reactivity: paraffin
- Control: tonsil (cytoplasmic)
- Dilution Range: 1:500-1:2000*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC22311040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1 mL concentrate | 223A-16 |
| 1 mL predilute ready-to-use | 223A-17 |
| 7 mL predilute ready-to-use | 223A-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1 mL concentrate | 223A-16 |
| 1 mL predilute ready-to-use | 223A-17 |
| 7 mL predilute ready-to-use | 223A-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1 mL concentrate | 223A-16 |
| 1 mL predilute ready-to-use | 223A-17 |
| 7 mL predilute ready-to-use | 223A-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 223A-14-RUO |
| 0.5 mL concentrate | 223A-15-RUO |
| 1 mL concentrate | 223A-16-RUO |
| 1 mL predilute ready-to-use (RUO) | 223A-17-RUO |
| 7 mL predilute ready-to-use (RUO) | 223A-18-RUO |
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