A-1-Antitrypsin Rabbit Polyclonal Antibody
Specialties: Hematopathology
Alpha-1-Antitrypsin is a protease inhibitor from the serpin superfamily, which inhibits a number of protease enzymes from inflammatory cells. It is an acute phase plasma protein predominantly produced in hepatocytes, although it is also made in enterocytes and some mononuclear white blood cells. Alpha-1-antitrypsin immunohistochemistry is used to detect the accumulation of alpha-1-antitrypsin in hepatic lesions and histiocytic tumors.1-8
- Callea, F et al. "Detection of Pi Z phenotype individuals by alpha-1-antitrypsin (AAT) immunohistochemistry in paraffin-embedded liver tissue specimens." Journal of hepatology vol. 2,3 (1986): 389-401.
- Palmer, P E et al. "Immunohistochemistry of liver in alpha1-antitrypsin deficiency. A comparative study." American journal of clinical pathology vol. 62,3 (1974): 350-4.
- Palmer, P E et al. "Expression of protein markers in malignant hepatoma: evidence for genetic and epigenetic mechanisms." Cancer vol. 45,6 (1980): 1424-31.
- Kindblom, L G et al. "Immunohistochemical investigations of tumors of supposed fibroblastic-histiocytic origin." Human pathology vol. 13,9 (1982): 834-40.
- Reintoft, I, and I E Hägerstrand. "Does the Z gene variant of alpha-1-antitrypsin predispose to hepatic carcinoma?." Human pathology vol. 10,4 (1979): 419-24.
- Ramsay, Alan D et al. "Variable antigen expression in hepatoblastomas." Applied immunohistochemistry & molecular morphology : AIMM vol. 16,2 (2008): 140-7.
- Molmenti, E P et al. "Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium." The Journal of clinical investigation vol. 92,4 (1993): 2022-34.
- Patel, Dhiren, and Jeffrey H Teckman. "Alpha-1-Antitrypsin Deficiency Liver Disease." Clinics in liver disease vol. 22,4 (2018): 643-655.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic)
- Dilution Range: 1:500-1:2000 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC22311050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1.0 mL concentrate | 223A-16 |
| 1.0 mL predilute ready-to-use | 223A-17 |
| 7.0 mL predilute ready-to-use | 223A-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1.0 mL concentrate | 223A-16 |
| 1.0 mL predilute ready-to-use | 223A-17 |
| 7.0 mL predilute ready-to-use | 223A-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 223A-14 |
| 0.5 mL concentrate | 223A-15 |
| 1.0 mL concentrate | 223A-16 |
| 1.0 mL predilute ready-to-use | 223A-17 |
| 7.0 mL predilute ready-to-use | 223A-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 223A-14-RUO |
| 0.5 mL concentrate (RUO) | 223A-15-RUO |
| 1.0 mL concentrate (RUO) | 223A-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 223A-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 223A-18-RUO |
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