Cyclin D1 (EP12) Rabbit Monoclonal Antibody
Specialties: Hematopathology
Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases.1 In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.1-3 This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative).4-7 Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.8
- Bartkova J, et al. Cancer Research. 1995; 55:949-956.
- Bartkova J, et al. Oncogene. 1995; 10:775-778.
- Bartkova J, et al. J Pathol. 1994; 172:237-245.
- Hankin RC, et al. Arch Pathol Lab Med. 1999; 123:1182-8.
- Yatabe Y, et al. Blood. 2000; 95:2253-61.
- Kodet R, et al. Virchows Arch. 2003; 442:538-47.
- Hui P, et al. Leuk Lymphoma. 2003; 44:1385-94.
- Swerdlow SH, et al. WHO Press. 2008; 189, 205.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: mantle cell lymphoma
- Dilution Range: 1:50-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC24134020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 241R-44 |
| 0.5 mL concentrate | 241R-45 |
| 1 mL concentrate | 241R-46 |
| 1 mL predilute | 241R-47 |
| 7 mL predilute | 241R-48 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 241R-44 |
| 0.5 mL concentrate | 241R-45 |
| 1 mL concentrate | 241R-46 |
| 1 mL predilute | 241R-47 |
| 7 mL predilute | 241R-48 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 241R-44 |
| 0.5 mL concentrate | 241R-45 |
| 1 mL concentrate | 241R-46 |
| 1 mL predilute | 241R-47 |
| 7 mL predilute | 241R-48 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 241R-44-RUO |
| 0.5 mL concentrate | 241R-45-RUO |
| 1 mL concentrate | 241R-46-RUO |
| 1 mL predilute | 241R-47-RUO |
| 7 mL predilute | 241R-48-RUO |
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