Cyclin D1 (EP12) Rabbit Monoclonal Antibody

Cyclin D1
Cyclin D1 (EP12) on mantle cell lymphoma.

Cyclin D1 (EP12) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases.1 In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.1-3 This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative).4-7 Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.8

  1. Bartkova J, et al. Cancer Research. 1995; 55:949-956.
  2. Bartkova J, et al. Oncogene. 1995; 10:775-778.
  3. Bartkova J, et al. J Pathol. 1994; 172:237-245.
  4. Hankin RC, et al. Arch Pathol Lab Med. 1999; 123:1182-8.
  5. Yatabe Y, et al. Blood. 2000; 95:2253-61.
  6. Kodet R, et al. Virchows Arch. 2003; 442:538-47.
  7. Hui P, et al. Leuk Lymphoma. 2003; 44:1385-94.
  8. Swerdlow SH, et al. WHO Press. 2008; 189, 205.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: mantle cell lymphoma
  • Dilution Range: 1:50-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate241R-44
0.5 mL concentrate241R-45
1 mL concentrate241R-46
1 mL predilute241R-47
7 mL predilute241R-48

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate241R-44
0.5 mL concentrate241R-45
1 mL concentrate241R-46
1 mL predilute241R-47
7 mL predilute241R-48

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate241R-44
0.5 mL concentrate241R-45
1 mL concentrate241R-46
1 mL predilute241R-47
7 mL predilute241R-48

For research use only (RUO) in Japan

0.1 mL concentrate241R-44-RUO
0.5 mL concentrate241R-45-RUO
1 mL concentrate241R-46-RUO
1 mL predilute241R-47-RUO
7 mL predilute241R-48-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information