CD56 (MRQ-42) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins.1-3 CD56 is involved in cell–cell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms,4 and is frequently used to identify neoplasms with neuroendocrine differentiation.5,6
- Walmod, Peter S et al. "Zippers make signals: NCAM-mediated molecular interactions and signal transduction." Neurochemical research vol. 29,11 (2004): 2015-35.
- Skog, Maria S et al. "Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells." Stem cell research & therapy vol. 7,1 113. 15 Aug. 2016.
- Cohavy, Offer, and Stephan R Targan. "CD56 marks an effector T cell subset in the human intestine." Journal of immunology (Baltimore, Md. : 1950) vol. 178,9 (2007): 5524-32.
- Swerdlow SH, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. 2008.
- Kriegsmann, Katharina et al. "Insulinoma-associated Protein 1 (INSM1) in Thoracic Tumors is Less Sensitive but More Specific Compared With Synaptophysin, Chromogranin A, and CD56." Applied immunohistochemistry & molecular morphology : AIMM vol. 28,3 (2020): 237-242.
- Rooper, Lisa M et al. "INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors." The American journal of surgical pathology vol. 42,5 (2018): 665-671.
Specifications
- Reactivity: paraffin
- Control: Neuroblastoma (Cytoplasmic, Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC15639040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 156R-94-RUO |
| 0.5 mL concentrate (RUO) | 156R-95-RUO |
| 1.0 mL concentrate (RUO) | 156R-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 156R-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 156R-98-RUO |
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