CD23 (SP23) Rabbit Monoclonal Antibody

CD23
Germinal center follicular dendritic cells show a strong cytoplasmic staining by CD23 antibody. Note the mantle cells demonstrate weak staining.

CD23 (SP23) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2018-01-11 08:58:44

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1  Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.2 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).

  1. Rowlands DC, et al. Immunohistochemical determination of CD23 expression in Hodgkin’s disease using paraffin sections. J Pathol. 1990; 160:239-43.
  2. DiRaimondo F, et al. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002; 94:1721-30.
  3. Raghoebier S, et al. Essential differences in oncogene involvement between primary nodal and extranodal large cell lymphoma. Blood. 1991; 78:2680-5.

Specifications


  • Reactivity: paraffin
  • Control: Tonsil, Lymph Node (Membranous); Chronic lymphocytic leukemia/Small lymphocytic lymphoma (Membranous)
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate123R-14
0.5 mL concentrate123R-15
1.0 mL concentrate123R-16
1.0 mL predilute ready-to-use123R-17
7.0 mL predilute ready-to-use123R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate123R-14
0.5 mL concentrate123R-15
1.0 mL concentrate123R-16
1.0 mL predilute ready-to-use123R-17
7.0 mL predilute ready-to-use123R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate123R-14
0.5 mL concentrate123R-15
1.0 mL concentrate123R-16
1.0 mL predilute ready-to-use123R-17
7.0 mL predilute ready-to-use123R-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)123R-14-RUO
0.5 mL concentrate (RUO)123R-15-RUO
1.0 mL concentrate (RUO)123R-16-RUO
1.0 mL predilute ready-to-use (RUO)123R-17-RUO
7.0 mL predilute ready-to-use (RUO)123R-18-RUO

 

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