Pit-1 (ZM385) Mouse Monoclonal Antibody
Specialties: Head/Neck Pathology Neuropathology
Detection of Pit-1 by immunohistochemistry with Pit-1 (ZM385) Mouse Monoclonal Antibody may be used to aid in the diagnosis of pituitary neuroendocrine tumors (pituitary adenomas).
Pituitary-specific transcription factor 1 (Pit-1) is a transcription factor that drives the production of prolactin, growth hormone (GH), and thyroid stimulating hormone (TSH) in the anterior pituitary gland.1 Pit-1 is expressed normally in the lactotroph, somatotroph, and thyrotroph cells of anterior pituitary gland, which produce these three pituitary hormones (prolactin, GH, and TSH). Immunohistochemistry for Pit-1 is positive in most lactotroph, somatotroph, and thyrotroph pituitary neuroendocrine tumors (pituitary adenomas).1-4 Immunohistochemistry for Pit-1 shows a nuclear pattern of staining.
- Ingraham, H A et al. "A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype." Cell vol. 55,3 (1988): 519-29.
- Asa, S L et al. "Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas." The Journal of clinical endocrinology and metabolism vol. 77,5 (1993): 1275-80.
- Lee, Julieann C et al. "Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas." Endocrine pathology vol. 28,4 (2017): 287-292.
- Jastania, R A et al. "Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation." Endocrine pathology vol. 16,3 (2005): 187-94.
Specifications
- Reactivity: paraffin
- Control: Pituitary (Nuclear); Pituitary Adenoma (Lactotroph) (Nuclear); Pituitary Adenoma (Somatotroph) (Nuclear); Pituitary Adenoma (Thyrotroph) (Nuclear)
- Dilution Range: 1:25-1:50 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC49621000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 496M-14 |
| 0.5 mL concentrate | 496M-15 |
| 1.0 mL concentrate | 496M-16 |
| 1.0 mL predilute ready-to-use | 496M-17 |
| 7.0 mL predilute ready-to-use | 496M-18 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 496M-14-RUO |
| 1.0 mL concentrate (RUO) | 496M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 496M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 496M-18-RUO |
For research use only (RUO) in the EU
| 0.1 mL concentrate (RUO) | 496M-14-RUO |
| 1.0 mL concentrate (RUO) | 496M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 496M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 496M-18-RUO |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 496M-14-RUO |
| 1.0 mL concentrate (RUO) | 496M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 496M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 496M-18-RUO |
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