Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

Claudin-4
Claudin-4 on lung adenocarcinoma.

Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

Specialties: Cytopathology Pulmonary Pathology

Updated: 2020-08-27 11:05:10

The claudin-family proteins are a group of tight-junction membranous proteins responsible for paracellular molecular flow between adjacent cells of the epithelium.1 In normal kidney, claudin-4 plays a key role in paracellular ion reabsorption.2 Claudin-4 is expressed in most epithelial cells yet is absent in mesothelial cells, making it of great use in characterizing epithelial malignincies.3 Immunohistochemical identification of this antigen may help identify poorly differentiated lung adenocarcinoma from lesions of mesothelial origin.4 Likewise, identification of claudin-4 expression by IHC may be useful in characterizing breast and endometrial lesions.5,6

  1. Cong X, et al. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. Journal of Cell Science 2015; 128:2271-2286.
  2. Hou J, et al. Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci USA 2010; 107(42):18010-5.
  3. Neesse A, et al. Claudin-4 as a therapeutic target in cancer. Arch Biochem Biphys; 2012; 524(1):64-70.
  4. Ordonez NG. Value of Claudin-4 immunostaining in the diagnosis of mesothelioma. Anatomic Pathology 2013; 139:611-619.
  5. Abd-Elazeem MA, et al. Claudin 4 expression in triple-negative breast cancer: correlation with androgen receptors and Ki-67 expression. Ann Diagn Pathol. 2015; 19(1):37-42.
  6. Konecny GE, et al. Claudin-3 and Claudin-4 expression in serous papillary, clear cell, and endometrioid endometrial cancer. Gynecol Oncol. 2008; 109(2):263-269.

Specifications


  • Reactivity: paraffin
  • Control: Lung adenocarcinoma (Membranous)
  • Dilution Range: 1:50-1:100 *

Package Inserts


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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate468R-14
0.5 mL concentrate468R-15
1.0 mL concentrate468R-16
1.0 mL predilute ready-to-use468R-17
7.0 mL predilute ready-to-use468R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate468R-14
0.5 mL concentrate468R-15
1.0 mL concentrate468R-16
1.0 mL predilute ready-to-use468R-17
7.0 mL predilute ready-to-use468R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate468R-14
0.5 mL concentrate468R-15
1.0 mL concentrate468R-16
1.0 mL predilute ready-to-use468R-17
7.0 mL predilute ready-to-use468R-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)468R-14-RUO
1.0 mL concentrate (RUO)468R-16-RUO
1.0 mL predilute ready-to-use (RUO)468R-17-RUO
7.0 mL predilute ready-to-use (RUO)468R-18-RUO

 

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