PD-1 (EP239) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Hematopathology
Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.1-6
- Bolstad AI, et al. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjögren’s syndrome. Arthritis Rheum. 2003; 48:174-85.
- Kobayashi M, et al. Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren’s syndrome. J Rheumatol. 2005; 32:2156-63.
- Hamanishi J, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A. 2007; 104:3360-5.
- Iwai Y, et al. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 2002; 83:215-20.
- Dorfman DM, et al. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2006; 30:802-10
- Konishi J, et al. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res. 2004; 10:5094-100.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: lymph node, tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC31531010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 315R-14 |
| 0.5 mL concentrate | 315R-15 |
| 1 mL concentrate | 315R-16 |
| 1 mL predilute | 315R-17 |
| 7 mL predilute | 315R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 315R-14 |
| 0.5 mL concentrate | 315R-15 |
| 1 mL concentrate | 315R-16 |
| 1 mL predilute | 315R-17 |
| 7 mL predilute | 315R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 315R-14 |
| 0.5 mL concentrate | 315R-15 |
| 1 mL concentrate | 315R-16 |
| 1 mL predilute | 315R-17 |
| 7 mL predilute | 315R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 315R-14-RUO |
| 0.5 mL concentrate | 315R-15-RUO |
| 1 mL concentrate | 315R-16-RUO |
| 1 mL predilute | 315R-17-RUO |
| 7 mL predilute | 315R-18-RUO |
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