STAT6 (EP325) Rabbit Monoclonal Antibody
Specialties: Soft Tissue Pathology
STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors.1-3 Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm.1 STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays.1 NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas.1-3 This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.
- Cheah AL, et al. Pathology. 2014; 46:389-95.
- Schweizer L, et al. Acta Neuropathol. 2013; 125:651-58.
- Koelsche C, et al. Histopathology. 2014; 65:613-22.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: solitary fibrous tumor
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC42631010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 426R-14 |
| 0.5 mL concentrate | 426R-15 |
| 1 mL concentrate | 426R-16 |
| 1 mL predilute | 426R-17 |
| 7 mL predilute | 426R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 426R-14 |
| 0.5 mL concentrate | 426R-15 |
| 1 mL concentrate | 426R-16 |
| 1 mL predilute | 426R-17 |
| 7 mL predilute | 426R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 426R-14 |
| 0.5 mL concentrate | 426R-15 |
| 1 mL concentrate | 426R-16 |
| 1 mL predilute | 426R-17 |
| 7 mL predilute | 426R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 426R-14-RUO |
| 0.5 mL concentrate | 426R-15-RUO |
| 1 mL concentrate | 426R-16-RUO |
| 1 mL predilute | 426R-17-RUO |
| 7 mL predilute | 426R-18-RUO |
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