CD13 (SP187) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD13 (aminopeptidase-N) is a transmembrane protease present in many tissues and cell types (e.g., endothelial and epithelial cells, fibroblasts, and leukocytes).1 CD13 is found in various solid and hematological malignancies in humans, including acute myeloid leukemia (AML), and is thought to influence tumor progression.2 It has also been reported that CD13 is expressed in both normal and neoplastic liver tissue, where it exhibits a canalicular distribution pattern.3 Thus, anti-CD13 can be a useful marker for identifying AML and hepatocellular carcinoma (HCC).1,3
- Bauvois B, et al. Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects. Med Res Rev.2006; 26:88-130.
- Piedfer M, et al. Aminopeptidase-N/CD13 is a potential pro-apoptotic target in human myeloid tumor cells. FASEB J. 2011; 25:2831-42.
- Rocken C, et al. Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma. J ClinPathol. 2005; 58:1069-75.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: liver
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC11331020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 113R-14 |
| 0.5 mL concentrate | 113R-15 |
| 1 mL concentrate | 113R-16 |
| 1 mL predilute | 113R-17 |
| 7 mL predilute | 113R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 113R-14 |
| 0.5 mL concentrate | 113R-15 |
| 1 mL concentrate | 113R-16 |
| 1 mL predilute | 113R-17 |
| 7 mL predilute | 113R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 113R-14 |
| 0.5 mL concentrate | 113R-15 |
| 1 mL concentrate | 113R-16 |
| 1 mL predilute | 113R-17 |
| 7 mL predilute | 113R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 113R-14-RUO |
| 0.5 mL concentrate | 113R-15-RUO |
| 1 mL concentrate | 113R-16-RUO |
| 1 mL predilute | 113R-17-RUO |
| 7 mL predilute | 113R-18-RUO |
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