C3d Rabbit Polyclonal Antibody
Specialties: Anatomic Pathology
Complement component C3 is an integral part of the classical, lectin, and alternative complement pathways, and its cleavage products are involved in immune responses such as opsonization and cell lysis. C3d is a fragment of C3 that normally binds to pathogen surfaces to promote B-cell activation. However, deposition of C3d has also been observed in peritubular capillaries of transplanted kidneys undergoing acute allograft rejection.1-3
- Bickerstaff A, et al. An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection. Am J Pathol. 2008; 173:347-57.
- Kuypers DR, et al. C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome. Transplantation. 2003; 76:102-8.
- Eggertsen G, et al. Complement deposition in renal allografts with early malfunction. APMIS. 2001; 109:825-34.
Specifications
- Reactivity: paraffin
- Control: Acute rejected kidney transplant (Cytoplasmic, Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 3.0 (CMC40317030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 403A-74 |
| 0.5 mL concentrate | 403A-75 |
| 1.0 mL concentrate | 403A-76 |
| 1.0 mL predilute ready-to-use | 403A-77 |
| 7.0 mL predilute ready-to-use | 403A-78 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 403A-74 |
| 0.5 mL concentrate | 403A-75 |
| 1.0 mL concentrate | 403A-76 |
| 1.0 mL predilute ready-to-use | 403A-77 |
| 7.0 mL predilute ready-to-use | 403A-78 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 403A-74 |
| 0.5 mL concentrate | 403A-75 |
| 1.0 mL concentrate | 403A-76 |
| 1.0 mL predilute ready-to-use | 403A-77 |
| 7.0 mL predilute ready-to-use | 403A-78 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 403A-74-RUO |
| 0.5 mL concentrate (RUO) | 403A-75-RUO |
| 1.0 mL concentrate (RUO) | 403A-76-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 403A-77-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 403A-78-RUO |
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