CD14 (EPR3653) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD14 is a 55kDa glycosyl-phosphatidylinositol-linked membrane protein, involved in endotoxin binding and recognition of apoptotic cells.1 CD14 is expressed on monocytes, macrophages, follicular dendritic cells, and granulocytes.2-4 Anti-CD14 can detect these cells, including monocyte-derived cells which are frequently increased in diffuse large B-cell lymphoma (DLBCL),3 as well as in neoplastic cells in acute myeloid leukemia with monocytic differentiation and chronic myelomonocytic leukemia.5
- Gregory CD, et al. CD14 and apoptosis. Apoptosis. 1999; 4:11-20.
- Wright SD, et al. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990; 249: 1431-33.
- Marmey B, et al. CD14 and CD169 expression in human lymph nodes and spleen: specific expansion of CD14+CD169- monocyte-derived cells in diffuse large B-cell lymphomas. Hum Pathol. 2006; 37:68-77.
- Smeltzer JP, et al. Pattern of CD14+ Follicular Dendritic Cells and PD1+ T Cells Independently Predicts Time to Transformation in Follicular Lymphoma. Clin Cancer Res. 2014; 20:2862-72.
- Rollins-Raval MA, et al. The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias. Histopathology. 2012; 60: 933-42.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: tonsil, lymph node, appendix, colon, myeloid leukemia
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 6.0 (CMC11431060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 114R-14 |
| 0.5 mL concentrate | 114R-15 |
| 1 mL concentrate | 114R-16 |
| 1 mL predilute | 114R-17 |
| 7 mL predilute | 114R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 114R-14 |
| 0.5 mL concentrate | 114R-15 |
| 1 mL concentrate | 114R-16 |
| 1 mL predilute | 114R-17 |
| 7 mL predilute | 114R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 114R-14 |
| 0.5 mL concentrate | 114R-15 |
| 1 mL concentrate | 114R-16 |
| 1 mL predilute | 114R-17 |
| 7 mL predilute | 114R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 114R-14-RUO |
| 0.5 mL concentrate | 114R-15-RUO |
| 1 mL concentrate | 114R-16-RUO |
| 1 mL predilute | 114R-17-RUO |
| 7 mL predilute | 114R-18-RUO |
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