Anti-claudin 1 stains colon adenocarcinoma in a cell membranous pattern.
Claudin 1 Rabbit Polyclonal Antibody
Specialties: Anatomic Pathology
Updated: 2017-05-24 08:46:09
Claudins are a family of over twenty proteins which are components of tight junctions. Tight junctions are specialized regions of cell-to-cell contact made up of a network of strands to act as a molecular ‘gasket’ for preventing the leakage of ions, water, etc., between cells.1 Claudin 1 has been shown to distinguish epithelial neoplasms from lymphomas, making it a useful marker for nearly all carcinomas.2
- Folpe AL, et al. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol. 2002; 26:1620-6.
- Soini Y. Expression of claudins 1, 2, 3, 4, 5, and 7 in various types of tumors. Histopathology. 2005; 47:551-60.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: neurofibroma, colon carcinoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC35911040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 359A-14 |
| 0.5 mL concentrate | 359A-15 |
| 1 mL concentrate | 359A-16 |
| 1 mL predilute | 359A-17 |
| 7 mL predilute | 359A-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 359A-14 |
| 0.5 mL concentrate | 359A-15 |
| 1 mL concentrate | 359A-16 |
| 1 mL predilute | 359A-17 |
| 7 mL predilute | 359A-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 359A-14 |
| 0.5 mL concentrate | 359A-15 |
| 1 mL concentrate | 359A-16 |
| 1 mL predilute | 359A-17 |
| 7 mL predilute | 359A-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 359A-14-RUO |
| 0.5 mL concentrate | 359A-15-RUO |
| 1 mL concentrate | 359A-16-RUO |
| 1 mL predilute | 359A-17-RUO |
| 7 mL predilute | 359A-18-RUO |
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