Kappa (L1C1) Mouse Monoclonal Antibody
Specialties: Hematopathology
Anti-Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.1-3
- Ashton-Key M, et al. Histopathology. 1996; 29:525-31.
- Kurtin PJ, et al. Am J Clin Pathol. 1999; 112:319-29.
- Abbondanzo SL, et al. Ann Diagn Pathol. 1999; 3:318-27.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC27429040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 274M-90 |
| 0.1 mL concentrate | 274M-94 |
| 0.5 mL concentrate | 274M-95 |
| 1 mL concentrate | 274M-96 |
| 1 mL predilute | 274M-97 |
| 7 mL predilute | 274M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 274M-90 |
| 0.1 mL concentrate | 274M-94 |
| 0.5 mL concentrate | 274M-95 |
| 1 mL concentrate | 274M-96 |
| 1 mL predilute | 274M-97 |
| 7 mL predilute | 274M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 274M-90 |
| 0.1 mL concentrate | 274M-94 |
| 0.5 mL concentrate | 274M-95 |
| 1 mL concentrate | 274M-96 |
| 1 mL predilute | 274M-97 |
| 7 mL predilute | 274M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 274M-94-RUO |
| 0.5 mL concentrate | 274M-95-RUO |
| 1 mL concentrate | 274M-96-RUO |
| 1 mL predilute | 274M-97-RUO |
| 7 mL predilute | 274M-98-RUO |
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