TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

TTF-1
Nuclear labelling of lung adenocarcinoma by TTF-1 antibody.

TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology Pulmonary Pathology

Updated: 2017-05-24 08:46:09

Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid1-2, germ cell tumors3, and malignant mesothelioma.4-5 It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.6 TTF-1 labeling is also seen in thyroid and thyroid-derived tumors.7 TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions.8 TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.9

  1. Bejarano PA, et al. Mod Pathol. 1996; 9:445-52.
  2. Holzinger A, et al. Hybridoma. 1996; 15:49-53.
  3. Saad RS, et al. Appl Immunohistochem Mol Morphol. 2003; 11:107-12
  4. Di Loreto C, et al. Cancer Lett. 1998; 124:73-8.
  5. Abutaily AS, et al. J Clin Pathol. 2002; 55:662-8.
  6. Di Loreto C, et al. J Clin Pathol. 1997; 50:30-2.
  7. Katoh R, et al. Mod Pathol. 2000; 13:570-6.
  8. Jang KY, et al. Anal Quant Cytol Histol. 2001; 23:400-4.
  9. Srodon M, et al. Hum Pathol. 2002; 33:642-5.
  10. Tan D, et al. Hum Pathol. 2003; 34:597-604.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: lung adenocarcinoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute343M-90
0.1 mL concentrate343M-94
0.5 mL concentrate343M-95
1 mL concentrate343M-96
1 mL predilute343M-97
7 mL predilute343M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute343M-90
0.1 mL concentrate343M-94
0.5 mL concentrate343M-95
1 mL concentrate343M-96
1 mL predilute343M-97
7 mL predilute343M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute343M-90
0.1 mL concentrate343M-94
0.5 mL concentrate343M-95
1 mL concentrate343M-96
1 mL predilute343M-97
7 mL predilute343M-98

For research use only (RUO) in Japan

25 mL predilute343M-90-RUO
0.1 mL concentrate343M-94-RUO
0.5 mL concentrate343M-95-RUO
1 mL concentrate343M-96-RUO
1 mL predilute343M-97-RUO
7 mL predilute343M-98-RUO

 

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