Villin (EP163) Rabbit Monoclonal Antibody

Villin
Villin (EP163) on colorectal carcinoma.

Villin (EP163) Rabbit Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium.1 This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs.2-5 This antibody also labels Merkel cells of the skin.6

  1. Leong AS-Y, et al. Manual of diagnostic antibodies for immnunohistochemistry. London: Greenwich Medical Media Ltd. 1999. Print. p. 162-168.
  2. Tan J, et al. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 1998; 29:390-6.
  3. Goldstein NS, et al. Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies. Am J Clin Pathol. 2001; 116:319-25.
  4. Tamboli P, et al. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: a report of 7 cases and investigation using a limited immunohistochemical panel. Arch Pathol Lab Med. 2002; 126:1057-63.
  5. Zhang PJ, et al. Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. Arch Pathol Lab Med. 1999; 123:812-6.
  6. Toyoshima K, et al. Identification of Merkel cells by an antibody to villin. J Histochem Cytochem. 1998; 46:1329-34.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: colon
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate346R-14
0.5 mL concentrate346R-15
1 mL concentrate346R-16
1 mL predilute346R-17
7 mL predilute346R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate346R-14
0.5 mL concentrate346R-15
1 mL concentrate346R-16
1 mL predilute346R-17
7 mL predilute346R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate346R-14
0.5 mL concentrate346R-15
1 mL concentrate346R-16
1 mL predilute346R-17
7 mL predilute346R-18

For research use only (RUO) in Japan

0.1 mL concentrate346R-14-RUO
0.5 mL concentrate346R-15-RUO
1 mL concentrate346R-16-RUO
1 mL predilute346R-17-RUO
7 mL predilute346R-18-RUO

 

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