IMP3 (EP286) Rabbit Monoclonal Antibody

IMP3
Cytoplasmic labelling by IMP3 antibody on pancreatic ductal adenocarcinoma.

IMP3 (EP286) Rabbit Monoclonal Antibody

Specialties: Cytopathology Anatomic Pathology

Updated: 2017-05-24 08:46:09

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 expression is at its highest during embryogenesis and silenced in normal human tissues (fibroblasts, lymphocytes, and testes are exceptions).1  IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys.2 IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues.1 In a study of IMP3 being used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis, IMP3 was found to have high sensitivity and specificity for pancreatic ductal adenocarcinoma and detected pancreatic ductal adenocarcinoma metastases.2 IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.1,2

  1. Schaeffer DF, et al. BMC Cancer. 2010; 10:59.
  2. Wachter D, et al. AM J Surg Pathol. 2011; 35:873-877.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: pancreatic ductal adenocarcinoma, placenta
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate433R-14
0.5 mL concentrate433R-15
1 mL concentrate433R-16
1 mL predilute433R-17
7 mL predilute433R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate433R-14
0.5 mL concentrate433R-15
1 mL concentrate433R-16
1 mL predilute433R-17
7 mL predilute433R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate433R-14
0.5 mL concentrate433R-15
1 mL concentrate433R-16
1 mL predilute433R-17
7 mL predilute433R-18

For research use only (RUO) in Japan

0.1 mL concentrate433R-14-RUO
0.5 mL concentrate433R-15-RUO
1 mL concentrate433R-16-RUO
1 mL predilute433R-17-RUO
7 mL predilute433R-18-RUO

 

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