S100P (16/f5) Mouse Monoclonal Antibody

S100P
S100P antibody labels both cytoplasmic and nuclear for tumor cells in pancreatic ductal adenocarcinoma.

S100P (16/f5) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

S100P is a member of the S100 family of proteins. The family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. Anti-S100P with nuclear or nuclear/cytoplasmic immunoreactivity can be seen in pancreatic ductal adenocarcinomas, while it is rarely detectable in benign pancreatic ducts. It may also help to distinguish urothelial carcinomas from other genitourinary neoplasms such as prostate carcinoma.1-6

  1. Lin F, et al. Diagnostic utility of S100P and von Hippel-Lindau gene product (pVHL) in pancreatic adenocarcinoma-with implication of their roles in early tumorigenesis. Am J Surg Pathol. 2008; 32:78-91.
  2. Deng HB, et al. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. Am J Clin Pathol. 2008; 129:81-8.
  3. Crnogorac-Jurcevi T, et al. Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. J Pathol. 2003; 201:63-74.
  4. Nakata K, et al. S100P is a novel marker to identify intraductal papillary mucinous neoplasms. Hum Pathol. 2010; 41:824-31.
  5. Higgins JP, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007; 31:673-80.
  6. Levy M, et al. S100P, von Hippel-Lindau gene product, and IMP3 serve as a useful immunohistochemical panel in the diagnosis of adenocarcinoma on endoscopic bile duct biopsy. Hum Pathol. 2010; 41:1210-9.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: pancreatic ductal adenocarcinoma, urothelial carcinoma, placenta
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate376M-94
0.5 mL concentrate376M-95
1 mL concentrate376M-96
1 mL predilute376M-97
7 mL predilute376M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate376M-94
0.5 mL concentrate376M-95
1 mL concentrate376M-96
1 mL predilute376M-97
7 mL predilute376M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate376M-94
0.5 mL concentrate376M-95
1 mL concentrate376M-96
1 mL predilute376M-97
7 mL predilute376M-98

For research use only (RUO) in Japan

0.1 mL concentrate376M-94-RUO
0.5 mL concentrate376M-95-RUO
1 mL concentrate376M-96-RUO
1 mL predilute376M-97-RUO
7 mL predilute376M-98-RUO

 

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