MUC5AC (MRQ-19) Mouse Monoclonal Antibody

MUC5AC
Gastric mucosa is labelled by MUC5AC antibody.

MUC5AC (MRQ-19) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

MUC5AC is a secretory mucin that is part of a family of at least 14 high molecular weight glycoproteins made by many epithelial tissues.1 MUC5AC is preferentially expressed in non-neoplastic gastric tissue and benign respiratory tract tissue.1 During neplastic transformation, mucin expression may be altered within these tissues leading to particular patterns of expression.1 Cytoplasmic expression of MUC5AC can be seen in carcinomas of the gastrointestinal tract, particularly those of esophagus and stomach, as well as the pancreatobiliary tract includng cholangiocarcinomas.1 Other tumors expressing MUC5AC include carcinomas of the endocervix endometrium and lung.1 MUC5AC immunoreactivity may also be seen in extramammary Paget's disease but it is not expressed in mammary paget's disease.2 Use of a panel of mucins including MUC1/MUC2/MUC5AC may be helpful with differential diagnosis in particular neoplastic settings.1 

  1. Lau SK, et al. Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Am J Clin Pathol. 2004; 122:61-9.
  2. Kuan, S. et al. Differential Expression of Mucin Genes in Mammary and Extramammary Paget’s Disease. Am J Surg Pathol. 2001; 25:1469-77.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: stomach
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate292M-94
0.5 mL concentrate292M-95
1 mL concentrate292M-96
1 mL predilute292M-97
7 mL predilute292M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate292M-94
0.5 mL concentrate292M-95
1 mL concentrate292M-96
1 mL predilute292M-97
7 mL predilute292M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate292M-94
0.5 mL concentrate292M-95
1 mL concentrate292M-96
1 mL predilute292M-97
7 mL predilute292M-98

For research use only (RUO) in Japan

0.1 mL concentrate292M-94-RUO
0.5 mL concentrate292M-95-RUO
1 mL concentrate292M-96-RUO
1 mL predilute292M-97-RUO
7 mL predilute292M-98-RUO

 

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