Myoepithelial cells of breast ducts are stained positive by anti-calponin in a cytoplasmic pattern.
Calponin (CALP) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Updated: 2017-05-24 08:46:09
Calponin is a 34-kD actin filament-associated regulatory protein that interacts with actin, tropomyosin, and calmodulin.1 It is involved in the smooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue and myoepithelial cells.2 Anti-calponin has been found to be useful marker for differentiating benign sclerosing lesions of the breast from invasive carcinoma.3
- Benson JR, et al. Early Breast Cancer: From Screening to Multidisciplinary Management, Third Edition. CRC Press, Jan 3, 2013.
- Liu R, et al. Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells. Gene. 2016; 585:143-53.
- Wang NP, et al. Antibodies to novel myoepithelium-associated proteins distinguish benign lesions and carcinoma in situ from invasive carcinoma of the breast. Appl. Immunohistochem. 5:141-51.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: appendix, breast, leiomyoma, uterus
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC23121040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 231M-14 |
| 0.5 mL concentrate | 231M-15 |
| 1 mL concentrate | 231M-16 |
| 1 mL predilute | 231M-17 |
| 7 mL predilute | 231M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 231M-14 |
| 0.5 mL concentrate | 231M-15 |
| 1 mL concentrate | 231M-16 |
| 1 mL predilute | 231M-17 |
| 7 mL predilute | 231M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 231M-14 |
| 0.5 mL concentrate | 231M-15 |
| 1 mL concentrate | 231M-16 |
| 1 mL predilute | 231M-17 |
| 7 mL predilute | 231M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 231M-14-RUO |
| 0.5 mL concentrate | 231M-15-RUO |
| 1 mL concentrate | 231M-16-RUO |
| 1 mL predilute | 231M-17-RUO |
| 7 mL predilute | 231M-18-RUO |
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